CD4+ T-lymphocytes are activated by surgical stress following colorectal resection in cancer patients
| Autor: | Seiichiro Hoshino, Shinsuke Takeno, Naoya Aisu, Masayasu Naito, Kanefumi Yamashita, Kenji Maki, Yuichi Yamashita |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Laparoscopic surgery
Cancer Research medicine.medical_specialty Surgical stress business.industry Colorectal cancer Lymphocyte medicine.medical_treatment Cancer medicine.disease Gastroenterology Surgery medicine.anatomical_structure Oncology Apoptosis Internal medicine White blood cell medicine business Abdominal surgery |
| Zdroj: | Molecular and Clinical Oncology. 3:79-82 |
| ISSN: | 2049-9469 2049-9450 |
| Popis: | The aim of the present study was to measure adenosine triphosphate (ATP) levels in CD4+ T cells as a marker of T-cell activity following surgery for colorectal cancer using the ImmuKnow assay kit. A total of 16 consecutive patients who underwent surgical resection for colorectal cancer between August and December, 2012 were enrolled in this study, of whom 7 underwent laparoscopic resection and 9 underwent open abdominal surgery. The intracellular ATP levels in CD4+ T-lymphocytes were measured using the ImmuKnow assay kit preoperatively and on the 1st, 4th and 8th postoperative days, as were the white blood cell (WBC) count, lymphocyte count and C-reactive protein (CRP) levels. The ATP level of the CD4+ T-cells was significantly elevated on the 1st day following surgery compared to the preoperative level (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|