Early enteral gut feeding with conditionally indispensable pharmaconutrients is metabolically safe and is well tolerated in postoperative cancer patients?a pilot study*1
| Autor: | Birgit Alteheld, Peter Stehle, M. Senkal, Rolf Haaker, Volker Zumtobel, Thomas Deska, Thomas Hummel, Claudia Steinfort |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Nutrition and Dietetics business.industry medicine.medical_treatment Vitamin E Critical Care and Intensive Care Medicine Enteral administration Gastroenterology Glutamine Parenteral nutrition Internal medicine Jejunostomy Vomiting medicine medicine.symptom business Flatulence Adverse effect |
| Zdroj: | Clinical Nutrition. 23:1193-1198 |
| ISSN: | 0261-5614 |
| DOI: | 10.1016/j.clnu.2004.03.010 |
| Popis: | Background & aims : Postoperative early enteral gut feeding with conditionally indispensable pharmaconutrients can contribute to minimize trauma-induced gut damage. Aim of this pilot study was the evaluation of metabolic effects and gastrointestinal tolerance of a new enteral supplement. Methods : In a prospective open clinical trial, 20 cancer patients received the test supplement containing glutamine (as dipeptides), antioxidative (pro-)vitamins (C, E, β -carotene), maltodextrine, tributyrine, sodium, zinc, and selenium within 2–3 h after elective gastrointestinal surgery continuously via jejunostomy tube for 3 postoperative days (500 ml/day). From postoperative day 3–5, additional enteral nutrition (1500 kcal/6270 kJ/day) was given. Metabolic effects (substrate monitoring, hematology, liver/kidney parameters) and tolerance (nausea, vomiting, flatulence, constipation, diarrhea) was assessed through the study. Results : Gastrointestinal tolerance of the supplement was excellent: no adverse events related to the product were documented. Significantly increased mean plasma levels (day 3 vs. day 1) of vitamin C (13.0±7.3 vs. 62.8±29.7 μmol/l), vitamin E (13.5±6.6 vs. 20.8±9.2 μmol/l), zinc (5.6±1.9 vs. 8.6±2.3 μmol/l) and selenium (35.0±19.6 vs. 42.9±0.9 μg/l) as well as enhanced plasma glutamine levels (429.6±90.6 vs. 530±200.1 μmol/l) reflected an effective absorption of substrates supplied. Adverse effects on organ functions and hematology were not observed. Conclusions : Early postoperative gut feeding with the newly developed enteral supplement shows no adverse effects, is well tolerated in cancer patients and provides a novel method to deliver conditionally indispensable pharmaconutrients. |
| Databáze: | OpenAIRE |
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