SkQR1 Reduces Neurologic Deficit Caused by Rat Brain Compression Ischemia
| Autor: | P D Rogozin, Vladimir G. Skrebitsky, Elena V. Stelmashook, O. P. Aleksandrova, Nickolay K. Isaev, E. E. Genrikhs, V. B. Sobolev, Svetlana Novikova |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
education.field_of_study business.industry Population Ischemia General Medicine Hippocampal formation medicine.disease Rat brain Body weight General Biochemistry Genetics and Molecular Biology In vitro model 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Anesthesia medicine Excitatory postsynaptic potential education business Compression time 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 170:590-593 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-021-05112-8 |
| Popis: | The protective effect of antioxidant SkQR1 was examined on the model of left-sided compression ischemia in rat sensorimotor cortex. The special tests aimed to determine the neurologic deficit in the limbs and assess performance of the forelimbs showed that a 2.5-min ischemia produced no disturbance in the limb functions on postsurgery days 1, 3, and 7. Elevation of compression time resulted in neurologic deficit in animals, and its severity depended on this time. A single intravenous injection of SkQR1 (250 nmol/kg body weight) performed 30 min after ischemia significantly reduced the degree of neurologic deficit. In vitro model of ischemia in surviving rat hippocampal slices showed that a 15-min-long ischemia significantly inhibited the population excitatory postsynaptic potentials, which did not restore during reperfusion. Preincubation of the slices with SkQR1 did not significantly affect recovery of these potentials. |
| Databáze: | OpenAIRE |
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