ANGIOTENSIN RECEPTOR SITES

Autor: Philip A. Khairallah, Alan F. Moore, Steve Gurchinoff
Rok vydání: 1977
Předmět:
DOI: 10.1016/b978-0-08-020933-3.50006-4
Popis: Publisher Summary This chapter discusses certain specialized receptor substances in tissues, with which drugs interact to produce a response. Cells are equipped with chemically reactive groups, with which drug molecules react as the first step in a biological response. It has been predicted that some sort of reciprocal relationship exists between the chemical structure of the drug molecule and the drug receptor. Angiotensinases are also present in plasma membranes, and the receptor sites and degrading sites are separate and distinguishable, although both bind peptide. The capacity to bind angiotensin and the capacity to activate biological responses are distinct processes and are dissociated. Thus, there is no direct relationship between hormone binding, receptor occupancy, and the magnitude of the response. In studying receptors, binding of a labeled hormone can be measured, which is difficult to interpret, or biological response, which may not be a direct one to one relation, can be measured. It also uses both binding and biological response data on angiotensin receptors.
Databáze: OpenAIRE