Two novel abietane norditerpenoids with anti-inflammatory properties from the roots of Salvia miltiorrhiza var. alba

Autor:	Longru Sun, Shuli Ma, Rong-Xiu Zhu, Hong-Xiang Lou, Tingting Xie
Rok vydání:	2014
Předmět:	Circular dichroism Vascular inflammation Stereochemistry medicine.drug_class Organic Chemistry Absolute configuration Biochemistry Salvia miltiorrhiza Norditerpenoids Anti-inflammatory chemistry.chemical_compound Biosynthesis chemistry Drug Discovery medicine Abietane
Zdroj:	Tetrahedron Letters. 55:7106-7109
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2014.10.153
Popis:	Salvialba acid (1) with a novel abietane norditerpenoid skeleton and 2-hydroxydihydrotanshinone I (2), a new abietane norditerpenoid, were isolated from Salvia miltiorrhiza var. alba. Their structures were elucidated by spectroscopic analysis and X-ray diffraction. The absolute configuration of 1 was determined by an electronic circular dichroism (ECD) experiment and TDDFT ECD computations. A possible biosynthesis pathway is proposed for 1. Compounds 1 and 2 were demonstrated to have anti-inflammatory effects on vascular inflammation induced by TNF-α in human aortic endothelial cells (HAECs).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c627e5ad8b553ccee41482e49d5487c4 https://doi.org/10.1016/j.tetlet.2014.10.153 Zobrazit plný text záznamu Full Text from ScienceDirect