Clinico-immunohistochemical Study of Oral Verruciform Xanthomas
| Autor: | Kazuhiko Tanio, Eisaku Ueta, Tetsuya Yamamoto, Kazuo Ryoke, Masami Shibata, Tokio Osaki, Isamu Kodani |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Weakly positive Pathology medicine.medical_specialty biology business.industry Connective tissue Vimentin Xanthoma medicine.disease Rete pegs Immune system medicine.anatomical_structure chemistry Keratin medicine biology.protein Immunohistochemistry Orthopedics and Sports Medicine Surgery Oral Surgery business |
| Zdroj: | Asian Journal of Oral and Maxillofacial Surgery. 17:95-99 |
| ISSN: | 0915-6992 |
| DOI: | 10.1016/s0915-6992(05)80031-7 |
| Popis: | Objective: To elucidate the immunohistochemical characteristics of oral verruciform xanthomas and the aetiology of foam cells. Patients and Methods: Oral verruciform xanthomas surgically extirpated from 5 patients were examined using immunohistochemistry. Results: The verruciform xanthomas revealed an accumulation of foam cells with clear cytoplasm in the connective tissue around the elongated epithelial rete pegs. The foam cells were intensely positive for CD-68, lysozyme, and vimentin, and were weakly positive for α-1-antitrypsin, but were negative for total keratin and S-100 protein. A small number of dendritic cells were found among the foam cells and were positive for S-100 protein. Conclusions: The findings suggest that the foam cells in oral verruciform xanthomas are of monocytemacrophage lineage and are associated with a local inflammatory immune mechanism similar to verruciform xanthomas of other organs. |
| Databáze: | OpenAIRE |
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