Toxicity assessment of TiO2-MWCNT nanohybrid material with enhanced photocatalytic activity on Danio rerio (Zebrafish) embryos
| Autor: | Regina Teresa Rosim Monteiro, Francine Côa, Laís Luz Rodrigues Neto, Gabriela H. da Silva, Hudson Wallace Pereira de Carvalho, Diego Stéfani T. Martinez, Latif U. Khan, Z. Clemente, Vera Lúcia S. S. De Castro |
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| Rok vydání: | 2018 |
| Předmět: |
animal structures
Health Toxicology and Mutagenesis Danio Nanoparticle 02 engineering and technology 010501 environmental sciences 01 natural sciences Nanomaterials medicine Yolk sac 0105 earth and related environmental sciences biology Chemistry Public Health Environmental and Occupational Health General Medicine 021001 nanoscience & nanotechnology biology.organism_classification Pollution Acute toxicity medicine.anatomical_structure embryonic structures Toxicity Photocatalysis Zebrafish embryo Biophysics 0210 nano-technology |
| Zdroj: | Ecotoxicology and Environmental Safety. 165:136-143 |
| ISSN: | 0147-6513 |
| DOI: | 10.1016/j.ecoenv.2018.08.093 |
| Popis: | The increasing production and use of nanomaterials is causing serious concerns about their safety to human and environmental health. However, the applications of titanium dioxide nanoparticles (TiO2NP) and multiwalled carbon nanotubes (MWCNT) hybrids has grown considerably, due to their enhanced photocatalytic efficiency. To our knowledge, there are no reports available to the scientific community about their toxicity. In this work, we perform a toxicity assessment of TiO2NP and TiO2-MWCNT nanohybrid materials using Zebrafish embryos standardized 96 h early life stage assay, under different exposure conditions (with and without UV light exposure). After exposure the parameters assessed were acute toxicity, hatching rate, growth, yolk sac size, and sarcomere length. In addition, μ-probe X-ray fluorescence spectroscopy (µ-XRF) was employed to observe if nanoparticles were uptaken by zebrafish embryos and consequently accumulated in their organisms. Neither TiO2NP nor TiO2-MWCNT nanohybrids presented acute toxicity to the zebrafish embryos. Moreover, TiO2NP presents sublethal effects for total length (with and without UV light exposure) on the embryos. This work contributes to the understanding of the potential adverse effects of the emerging nanohybrid materials towards safe innovation approaches in nanotechnology. |
| Databáze: | OpenAIRE |
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