Inhibitory Effects of Functional Sujeonggwa Drinks on Hepatic Lipid Accumulation in Hypercholesterolemic ApoE Knockout Mice
| Autor: | Jee Hyun Lee, Aran Baek, Yeong Ok Song, Seulki Kim, Koeun Jung, Mijeong Kim |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Apolipoprotein E
medicine.medical_specialty Nutrition and Dietetics biology Chemistry Thiobarbituric acid Fructooligosaccharide Metabolism Reductase Sterol Sterol regulatory element-binding protein chemistry.chemical_compound Fatty acid synthase Endocrinology Biochemistry Internal medicine medicine biology.protein lipids (amino acids peptides and proteins) Food Science |
| Zdroj: | Journal of the Korean Society of Food Science and Nutrition. 43:1648-1657 |
| ISSN: | 1226-3311 |
| DOI: | 10.3746/jkfn.2014.43.11.1648 |
| Popis: | In this study, the hepatic lipid-lowering effects and related mechanism of action of sujeonggwa were examined in hypercholesterolemia-induced apoprotein E knockout (apo E ko) mice. Sujeonggwa drink was prepared with cinnamon, ginger, and sugar by modifying the traditional recipe of sujeonggwa. Sugar was partially substituted with either stevia or short chain fructooligosaccharide (scFOS) in order to reduce the calorie content of sujeonggwa, which was measured by descriptive analysis. Apo E ko mice (n=42) were induced to have hypercholesterolemia (plasma total cholesterol concentration >1,000 mg/dL) by administration of a high cholesterol diet for 4 weeks, followed by division into six groups. Experimental groups were orally administered water as a vehicle (normal group), sugar solution (control group), commercially available 'V' sujeonggwa drink (positive control group), or three different types of sujeonggwa drinks (S-sugar, S-stevia, and S-scFOS group) for 6 weeks while high cholesterol diet was provided to all animals. Compared to the control group, concentrations of hepatic triglycerides, total cholesterol, thiobarbituric acid reactive substances, and reactive oxygen species in S-sugar, S-stevia, S-scFOS were significantly reduced (P |
| Databáze: | OpenAIRE |
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