Biofunctional rapid prototyping for tissue-engineering applications: 3D bioplotting versus 3D printing
| Autor: | Rainer Schmelzeisen, Andreas Pfister, Andres Laib, Rüdiger Landers, U. Hübner, Rolf Mülhaupt |
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| Rok vydání: | 2003 |
| Předmět: |
Rapid prototyping
Materials science Polymers and Plastics Polymer science Starch Scanning electron microscope business.industry Organic Chemistry 3D printing Ethyl ester chemistry.chemical_compound chemistry Chemical engineering Tissue engineering Materials Chemistry Biodegradable polyurethane Isophorone diisocyanate business |
| Zdroj: | Journal of Polymer Science Part A: Polymer Chemistry. 42:624-638 |
| ISSN: | 0887-624X |
| DOI: | 10.1002/pola.10807 |
| Popis: | Two important rapid-prototyping technologies (3D Printing and 3D Bioplotting) were compared with respect to the computer-aided design and free-form fabrication of biodegradable polyurethane scaffolds meeting the demands of tissue-engineering applications. Aliphatic polyurethanes were based on lysine ethyl ester diisocyanate and isophorone diisocyanate. Layer-by-layer construction of the scaffolds was performed by 3D Printing, that is, bonding together starch particles followed by infiltration and partial crosslinking of starch with lysine ethyl ester diisocyanate. Alternatively, the 3D Bioplotting process permitted three-dimensional dispensing and reactive processing of oligoetherurethanes derived from isophorone diisocyanate, oligoethylene oxide, and glycerol. The scaffolds were characterized with X-ray microtomography, scanning electron microscopy, and mechanical testing. Osteoblast-like cells were seeded on such scaffolds to demonstrate their potential in tissue engineering. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 624–638, 2004 |
| Databáze: | OpenAIRE |
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