Ist die routinemäßige Skelettszintigraphie in der Nachsorge des Mammakarzinoms gerechtfertigt?

Autor:	Dudzak R, Gabl F, Lenzhofer R, Pirich K, Schuster R
Rok vydání:	2008
Předmět:	medicine.medical_specialty business.industry Retrospective cohort study Skeletal scanning General Medicine medicine.disease Gastroenterology Bone scanning Breast cancer Internal medicine medicine Carcinoma Alkaline phosphatase Radiology medicine.symptom business Bone pain Statistical correlation
Zdroj:	DMW - Deutsche Medizinische Wochenschrift. 109:1639-1642
ISSN:	1439-4413 0012-0472
DOI:	10.1055/s-2008-1069427
Popis:	In a retrospective study of 254 women with carcinoma of the breast (mean age 55.4 years) the occurrence of bone pain was compared with results of skeletal scanning, skeletal X-ray examinations and routine biochemical findings. Typical signs of skeletal metastases were found in bone scans of 119 patients, 88 (74%) of whom had bone pain. Alkaline phosphatase was elevated in 54 (45%), LDH in 32 (27%), and gamma-GT in 69 patients (58%). There was a statistical correlation between the number of affected skeletal parts and the absolute level of alkaline phosphatase (P less than 0.001) and of LDH (P less than 0.05). Skeletal scans gave no evidence of bone metastases in 36 patients who had bone pains. In this group of patients alkaline phosphatase was elevated in 4, LDH in 1 and gamma-GT in 12 patients. Routine scanning of 254 patients revealed skeletal metastases in 12% without any clinical symptoms. Bone pain and (or) increased activity of alkaline phosphatase occurred in 91% of patients with skeletal metastases. In our view, bone scan in the postoperative control of breast cancer is justified only after onset of clinical symptoms and (or) if there is an abnormally raised alkaline phosphatase activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c5f27e0a7cfa5cbc91a5db595acaa850 https://doi.org/10.1055/s-2008-1069427 Zobrazit plný text záznamu