Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA- complements

Autor:	Chantal Jouanno, Alain De Mesmaeker, Valérie Fritsch, Romain M. Wolf, Sebastian Wendeborn
Rok vydání:	1997
Předmět:	Molecular model medicine.drug_class Oligonucleotide Stereochemistry Organic Chemistry Clinical Biochemistry Substituent Pharmaceutical Science RNA Carboxamide Biochemistry chemistry.chemical_compound chemistry Amide Drug Discovery medicine Molecular Medicine Chemical stability Molecular Biology DNA
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 7:1869-1874
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(97)00318-1
Popis:	The synthesis of the amide dimers 3–5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (Tm's) of the corresponding duplexes with RNA- and DNA- complements, and a summary of molecular modeling studies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c5ea8163dea05916f274d56efb25c86a https://doi.org/10.1016/s0960-894x(97)00318-1 Zobrazit plný text záznamu Full Text from ScienceDirect