ChemInform Abstract: 5-Hydroxypentane-2,3-dione (Laurencione), a Bacterial Metabolite of 1-Deoxy-D-threo-pentulose

Autor:	Albert Boronat, Michel Rohmer, Narciso Campos, Knut Danielsen, Surya Rosa Putra, Lionel Charon, Catherine Pale-Grosdemange, Luisa Maria Lois
Rok vydání:	2010
Předmět:	chemistry.chemical_compound Klebsiella biology chemistry Stereochemistry Metabolite medicine General Medicine biology.organism_classification medicine.disease_cause Escherichia coli Bacteria
Zdroj:	ChemInform. 29
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.199845214
Popis:	Cell-free systems from the bacteria Escherichia coli and Klebsiella planticola that were incubated with 13 C labeled pyruvate and D-glyceraldehyde synthesized 5-hydroxypentane-2,3-dione (laurencione) along with 1-deoxy-D- threo -pentulose (1-deoxy-D-xylulose). Both compounds showed identical labeling patterns, indicating that the C 5 skeletons were derived from the condensation of (hydroxyethyl)thiamin on D-glyceraldehyde. Conversion of [5,5- 2 H 2 ]deoxyxylulose into laurencione by a cell-free system from E. coli showed that the α-dione is obtained from the pentulose by water elimination.
Databáze:	OpenAIRE
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