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The sections in this article are Introduction Superparamagnetic Nanoparticles Agglomeration-Based Sensing T2 Sensitivity of MRSW Particles Fundamentals of T2 Relaxation Detecting T2 Relaxation Theoretical Model for T2 and Nanoparticle Size Kinetics of Magnetic Relaxation Switch Biosensors Demonstrations of Magnetic Relaxation Switch Biosensors Detecting Nucleic Acids Detecting Proteins Detecting Enzymes Detecting Viruses Detecting Small Molecules Detecting Ions Detecting Cells Methods Development Reagent Synthesis, Preparation, and Characterization Measurement and Sensitivity Enhancement Methods Micro-NMR of Magnetic Relaxation Switch Biosensors Acknowledgments Keywords: nanoparticles; superparamagnetism; diagnostics; biosensor; nuclear magnetic resonance; portable detectors |