Observations of endotoxin-like activity associated with the Legionnaires' disease bacterium

Autor:	Donald C. Mackel, Roger L. Anderson, Anita K. Highsmith, David W. Fraser, William B. Baine
Rok vydání:	1978
Předmět:	Amebocyte Lysis Gram-negative bacteria biology Inoculation General Medicine biology.organism_classification medicine.disease Applied Microbiology and Biotechnology Microbiology Tap water Biological property medicine Legionnaires' disease Bacteria
Zdroj:	Current Microbiology. 1:315-317
ISSN:	1432-0991 0343-8651
DOI:	10.1007/bf02601690
Popis:	Suspensions of Legionnaires' disease bacterium stored in sterilized tap water 279–287 days produced gelation ofLimulus amebocyte lysate. A 1-ml suspension of washed cells containing 109 viable organisms had aLimulus amebocyte lysate activity equivalent to 4 mg of endotoxin. This activity remained stable in samples that had been autoclaved at 121°C for 15 min. Both the autoclaved cells and filtrate of autoclaved cells were pyrogenic in inoculated rabbits. The Legionnaires' disease bacterium produces a substance or substances that have biological properties associated with endotoxin of more typical Gram-negative bacteria.
Databáze:	OpenAIRE
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