Predictive value of urinary (NAG), alanme-aminopeptidase(AAP) and beta-2-microglobulin (β2M) in evaluating nephrotoxicity of gentamicin
| Autor: | Daniel Alber, Henry Jc, Gibey R, J.L. Dupond, Robert Leconte des Floris |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Creatinine
medicine.medical_specialty urogenital system business.industry Beta-2 microglobulin Urinary system Biochemistry (medical) Clinical Biochemistry General Medicine Urine urologic and male genital diseases Biochemistry Aminopeptidase Nephrotoxicity Surgery chemistry.chemical_compound Endocrinology chemistry Internal medicine Medicine Gentamicin Glucosaminidase business medicine.drug |
| Zdroj: | Clinica Chimica Acta. 116:25-34 |
| ISSN: | 0009-8981 |
| Popis: | Concentrations of N- acetyl-beta- d -glucosaminidase (NAG), alanine-aminopeptidase (AAP) and beta-2-microglobulin ( β 2 M) were determined daily in the urine of 28 patients treated with gentamicin (2–3 mg·kg −1 · day −1 ) for a mean of 15 days. All had normal renal function. Increased activity in NAG and AAP was observed for all patients, either immediately or after 2 or 3 days of treatment. The results were compared with serum creatinine concentrations and urinary β 2 M levels. This study indicates a relationship between the nephrotoxicity of gentamicin and initial urinary enzymic activity (NAG i ) prior to any treatment. The degree of NAG response during the first ten days of treatment appeared as a second prognostic factor. Renal failure was observed for one out of the 12 patients with normal NAG i (NAG i 1500 μmol/day) with an increase in β 2 M activity. Eleven out of the 16 patients with elevated NAG i (NAG i > 200 μmol/day) developed renal failure and showed an elevated maximal response. The concentration of AAP appears to be of little prognostic value. The variation in individual maximal urinary enzyme responses observed among the 28 patients during the first ten days of treatment points to the existence of individual sensitivities to gentamicin, the exact mechanism of which remains unclear. |
| Databáze: | OpenAIRE |
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