'All that glisters is not gold': Ultrafiltration and free thyroxine measurement

Autor:	John E.M. Midgley
Rok vydání:	2011
Předmět:	Free thyroxine measurement medicine.medical_specialty Semipermeable membranes Chromatography Chemistry Clinical Biochemistry Ultrafiltration General Medicine Free thyroxine Gold standard (test) Endocrinology Internal medicine medicine Free form
Zdroj:	Clinical Biochemistry. 44:151-153
ISSN:	0009-9120
DOI:	10.1016/j.clinbiochem.2010.11.001
Popis:	Objective To examine the merits of measuring free analytes by ultrafiltration using either diluted or undiluted serum. Results Confidence in the accuracy of measurements is affected both by problems identified in current systems using semipermeable membranes, the sensitivity of the system to artefacts and comparisons with other imperfect assays. Conclusion All “gold standard” methods must robustly obey sound physicochemical principles if valid conclusions are to be drawn.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c5e278c57e538c56f26306b07ba49b8b https://doi.org/10.1016/j.clinbiochem.2010.11.001 Zobrazit plný text záznamu Full Text from ScienceDirect