Flavones and New Isoflavone Derivatives from Microorganisms: Isolation and Structure Elucidation
| Autor: | Ratnakar N. Asolkar, Iris Grün-Wollny, Hartmut Laatsch, Volker Hoffman, Werner F. Fleck, Rajendra P. Maskey, Michael Speitling |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
Aromatic acid biology 010405 organic chemistry Chemistry Daidzein Ether General Chemistry biology.organism_classification 01 natural sciences Streptomyces Flavones 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Isoflavonoid Apigenin Organic chemistry Bacteria |
| Zdroj: | Zeitschrift für Naturforschung B. 58:686-691 |
| ISSN: | 1865-7117 0932-0776 |
| Popis: | In the course of our chemical screening of actinomycetes and other bacteria from terrestrial and marine sources, several extracts showed colourless middle polar bands with strong UV absorption at 254 nm and brown to grey colouration with anisaldehyde/sulphuric acid. Working-up of such strains led to the isolation of a number of isoflavonoids. Daidzein (la) and genistein (1b) are very wide-spread, however, compounds like kakkatin (2b, Streptomyces sp. GW39/1530) were known only from plant sources. Additionally, three new isoflavonoids were obtained, namely 4',7-bis-(β-cymaropyranosyl)-genistein (le) and 4'-hydroxy-6,7-methoxyisoflavone (2c) from the actinomycete isolate HKI 129-L, and genistein-4'-(6"-methyl)-salicylate (1d) from Streptomyces sp. isolate GW27/2506. 1d is the first natural 4'-ester of an isoflavonoid and an aromatic acid. For the first time, also two flavonoids were isolated from bacteria, apigenin (5a) and luteolin-3'-methyl ether (5b). |
| Databáze: | OpenAIRE |
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