Influence of Intestinal Strangulation Release on Ischemiareperfusion Injury in Sprague Dawley Rats
| Autor: | Dorothy Dorothy, Rizky Amaliah, Ahmad Yani |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment medicine.disease_cause Malondialdehyde Gastroenterology Resection chemistry.chemical_compound Intestinal mucosa chemistry Internal medicine Distal ileum Laparotomy Intestine injury Sprague dawley rats medicine Surgery business Oxidative stress |
| Zdroj: | Annals of African Surgery. 18:90-95 |
| ISSN: | 2523-0816 1999-9674 |
| DOI: | 10.4314/aas.v18i2.6 |
| Popis: | Background: In intestinal ischemia, reperfusion towards the injured intestine can cause further injury to the intestine itself and to remote organs. This research aimed to evaluate the influence of intestinal strangulation release (SR) before resection on the intestine outside margin of the strangulated intestine compared with subjects without intestinal strangulation release (WSR). Methods: Fourteen male Sprague Dawley rats were subjected to strangulation of one loop of the distal ileum for 4 h. In the SR group, the strangulated intestine was released for 5 min and then resected for necrotic parts. In the WSR group, the strangulated intestine was immediately resected WSR. The control group received a sham laparotomy. Four hours after the second laparotomy, the animals weresacrificed, and intestinal samples were taken for histomorphological analysis and measurement of intestinal malondialdehyde (MDA) level. Results: The injury on the histomorphological intestinal mucosa and intestinal MDA level were insignificantly higher in the SR group than in the WSR group (p>0.05). Conclusion: Intestinal SR before resection causes more tissue injury and oxidative stress on the intestine outside the strangulationsection, but the difference is not statistically significant. Keywords: Ischemia-reperfusion injury, Intestinal ischemia, Intestinal strangulation release, Malondialdehyde, Intestine injury |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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