Effects of low-intensity pulsed ultrasound stimulation on porous hydroxyapatite blocks for posterolateral fusion of lumbar spine in rabbits
| Autor: | Bin Liu, Hong-bin Lü, Ying Zhang, Xi-yang Wang, Xiang-long Zhuo, Da-qi Xu, HU Jian-zhong |
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| Rok vydání: | 2010 |
| Předmět: |
Materials science
Bone density medicine.diagnostic_test business.industry Radiography Metals and Alloys Stimulation Low-intensity pulsed ultrasound Geotechnical Engineering and Engineering Geology Condensed Matter Physics Palpation Posterolateral fusion Untreated control Materials Chemistry medicine Lumbar spine business Nuclear medicine |
| Zdroj: | Transactions of Nonferrous Metals Society of China. 20:1921-1927 |
| ISSN: | 1003-6326 |
| DOI: | 10.1016/s1003-6326(09)60396-4 |
| Popis: | The effects of porous hydroxyapatite blocks (PHABs) and an adjunct low-intensity pulsed ultrasound stimulation (LIPUS) on the fusion rate in a rabbit spinal posterolateral fusion (PLF) model were evaluated. Twenty rabbits underwent PLF with autograft and PHABs were randomly assigned to two groups: treated group with 20 min LIPUS daily and untreated control group for 4 weeks until euthanasia. The fused motion segments were subjected to manual palpation, gross observation, and radiographic investigation before histomorphologic and scanning electron microscopic analyses. Statistical differences between the LIPUS group and the control group are found in the fusion rate, bone density gray scale, trabecular bone formation, osteoblast-like cells, chondrocytes and positive expression of BMP-2 and TGF-β1 in the junction zone (significance level p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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