Assessment of Anti-atopic Dermatitis Activity of Oroxylum indicum Extract Incorporated Cream
| Autor: | Do Hoang Thu Trang, Hoang Le Son |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oroxylum
Traditional medicine biology business.industry Acanthosis Atopic dermatitis medicine.disease biology.organism_classification Oroxylum indicum Tacrolimus 2 4-Dinitrochlorobenzene 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry medicine medicine.symptom Parakeratosis business 030217 neurology & neurosurgery Spongiosis |
| Zdroj: | Journal of Pharmaceutical Research International. 17:1-11 |
| ISSN: | 2456-9119 |
| DOI: | 10.9734/jpri/2017/34325 |
| Popis: | Aims: The search for plant-based treatments against atopic dermatitis (AD), a relapsing dermatological condition with high prevalence in tropical regions, has always been attracting special attention. Among many folk remedies for AD, Oroxylum indicum Linn (Bignoniaceae) is a commonly used medicinal plant whose effectiveness has not yet been scientifically reported. This study thus aimed to investigate the anti-AD activity of ethyl acetate extract from the bark of Oroxylum indicum. Methodology: Five cream formulations containing Oroxylum indicum ethyl acetate bark extract in different concentrations (0%, 1.25%, 2.5%, 3.75%, and 5%) were topically applied onto the dorsal skin of 2,4-dinitrochlorobenzene-sensitized BALB/C mice once a day during 6 weeks. Phosphate-Buffered Saline (PBS) and Protopic (Tacrolimus 0.1%) were used as negative and positive control, respectively. All mice were subjected to the assessment of AD-like symptoms including the development of eczematous skin lesions, intensity of pruritus and histological alterations. Results: The plant extract at 5% was significantly effective in suppressing the dermatitis scores by 23.26% (n=6, p |
| Databáze: | OpenAIRE |
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