Resection margins in oral cancer surgery: Room for improvement
| Autor: | Gerwin J. Puppels, Tom C. Bakker Schut, Robert J. Baatenburg de Jong, Emilie A. C. Dronkers, Aniel Sewnaik, V Noordhoek Hegt, Jose A. Hardillo, Ton P. M. Langeveld, Ivo ten Hove, Cees A. Meeuwis, Senada Koljenović, Jan Molenaar, Roeland W.H. Smits |
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| Rok vydání: | 2015 |
| Předmět: |
Mouth neoplasm
medicine.medical_specialty business.industry Oral surgery General surgery Head and neck cancer Head neck Distant metastasis medicine.disease Surgery Resection 03 medical and health sciences 0302 clinical medicine Otorhinolaryngology 030220 oncology & carcinogenesis medicine Overall survival 030223 otorhinolaryngology business Cancer surgery |
| Zdroj: | Head & Neck. 38:E2197-E2203 |
| ISSN: | 1043-3074 |
| DOI: | 10.1002/hed.24075 |
| Popis: | The purpose of this review was to identify publications on resection margins in oral cancer surgery and compare these with the results from 2 Dutch academic medical centers. Eight publications were considered relevant for this study, reporting 30% to 65% inadequate resection margins (ie, positive and close margins), compared to 85% in Dutch centers. However, clinical outcome in terms of overall survival and recurrence seemed comparable. The misleading difference is caused by lack of unanimous margin definition and differences in surgicopathological approaches. This prevents comparison between the centers. Data from Dutch centers showed that inadequate resection margins have a significantly negative effect on local recurrence, regional recurrence, distant metastasis, and overall survival. These results confirm the need for improvement in oral cancer surgery. We underline the need for consistent protocols and optimization of frozen section procedures. We comment on development of optical techniques for intraoperative assessment of resection margins. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2197-E2203, 2016. |
| Databáze: | OpenAIRE |
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