Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a 1H-MR spectroscopy study
| Autor: | Yuji Suzuki, Kenichi Yamada, Masaki Watanabe, Hironaka Igarashi, Satoshi Ueki, Mami Shimizu, Tsutomu Nakada |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Pediatrics 1h nmr spectroscopy business.industry Glutamate receptor 030218 nuclear medicine & medical imaging 03 medical and health sciences Normal volunteers Occipital Cortices 0302 clinical medicine medicine.anatomical_structure Endocrinology Repetition Time Age groups Cerebral cortex Internal medicine Pediatrics Perinatology and Child Health medicine Young adult business 030217 neurology & neurosurgery |
| Zdroj: | Pediatric Research. 82:749-752 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | The aim of the present study was to investigate maturational changes in glutamate (Glu) in the human cerebral cortex from childhood to young adulthood using 3.0-Tesla proton magnetic resonance spectroscopy (1H-MRS), which is capable of quantifying Glu in vivo. Normal volunteers comprising 11 children (aged 4–13 years) and 11 young adults (aged 18–33 years) participated in the study. Single-voxel point-resolved spectroscopy (PRESS, repetition time/echo time=2,000/80 ms) was performed on the frontal and occipital cortices, and the Glu-to-creatine ratio (Glu/Cr) and N-acetylaspartate-to-creatine ratio (NAA/Cr) were determined. In both the frontal and occipital cortices, Glu/Cr was significantly lower during young adulthood relative to that during childhood. NAA/Cr did not differ significantly between the two age groups. This study has provided objective evidence that cerebral cortical Glu/Cr decreases between childhood and young adulthood. The observed decrease in Glu/Cr may reflect the simultaneous occurrence of maturational changes, such as changes in cortical microstructure and the intercellular compartmentation of Glu metabolism. |
| Databáze: | OpenAIRE |
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