PTSD Psychotherapy Outcome Predicted by Brain Activation During Emotional Reactivity and Regulation
| Autor: | Allison L. Thompson, James J. Gross, Gregory A. Fonzo, Yevgeniya V. Zaiko, Amit Etkin, Meredith Harvey, M. Elizabeth Weiss, Desmond J. Oathes, Bruce A. Arnow, Booil Jo, Sanno E. Zack, Steven E. Lindley, Barbara O. Rothbaum, Kathy Peng, Madeleine S. Goodkind |
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| Rok vydání: | 2017 |
| Předmět: |
Brain activation
Psychotherapist medicine.medical_treatment Exposure therapy behavioral disciplines and activities Outcome (game theory) 030227 psychiatry Prolonged exposure Transcranial magnetic stimulation 03 medical and health sciences Psychiatry and Mental health Posttraumatic stress 0302 clinical medicine medicine Effective treatment Psychology Reactivity (psychology) 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | American Journal of Psychiatry. 174:1163-1174 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | Objective:Exposure therapy is an effective treatment for posttraumatic stress disorder (PTSD), but many patients do not respond. Brain functions governing treatment outcome are not well characterized. The authors examined brain systems relevant to emotional reactivity and regulation, constructs that are thought to be central to PTSD and exposure therapy effects, to identify the functional traits of individuals most likely to benefit from treatment.Method:Individuals with PTSD underwent functional MRI (fMRI) while completing three tasks assessing emotional reactivity and regulation. Participants were then randomly assigned to immediate prolonged exposure treatment (N=36) or a waiting list condition (N=30). A random subset of the prolonged exposure group (N=17) underwent single-pulse transcranial magnetic stimulation (TMS) concurrent with fMRI to examine whether predictive activation patterns reflect causal influence within circuits. Linear mixed-effects modeling in line with the intent-to-treat principle w... |
| Databáze: | OpenAIRE |
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