Direct effects of expectorants on the tracheobronchial system in vivo
| Autor: | Miwa Misawa, Saizo Yanaura, Sumiko Sasagawa, Tomokazu Hosokawa |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Pharmacology
medicine.medical_specialty Chemistry Bromhexine chemistry.chemical_element respiratory system Iodine chemistry.chemical_compound Endocrinology medicine.anatomical_structure In vivo Pilocarpine Internal medicine medicine Bronchoconstriction medicine.symptom Expectorant Histamine medicine.drug Respiratory tract |
| Zdroj: | Journal of Pharmacobio-Dynamics. 2:127-132 |
| ISSN: | 1881-1353 0386-846X |
| DOI: | 10.1248/bpb1978.2.127 |
| Popis: | Direct actions of expectorants and other secretagogues on the airway system in vivo were investigated. Bronchosecretory, bronchomotor and bronchovascular responses were determined in pentobarbital-anesthetized dogs, the bronchial artery of which was perfused with blood in situ. Pilocarpine and histamine had a direct strong stimulating effect on the airway secretory cells, and potassium iodide and ammonium chloride had a mild effect, while bromhexine had almost no stimulant effect on those cells. Potassium iodide and bromhexine produced a slight bronchoconstriction. Contribution of a transvascular transudate to the respiratory tract fluid produced by expectorants or other secretagogues was suggested to be quite small. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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