Effect of iron oxide nanoparticles on the blood coagulation according to light scattering data
| Autor: | Anatoly Masalov, L. L. Chaikov, Nikolay Bulychev, M. N. Kirichenko, Mishik A. Kazaryan |
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| Rok vydání: | 2018 |
| Předmět: |
010302 applied physics
Materials science biology Oxide Nanoparticle 01 natural sciences Fibrin Light scattering Ferrous 010309 optics chemistry.chemical_compound chemistry Chemical engineering Dynamic light scattering 0103 physical sciences biology.protein Static light scattering Iron oxide nanoparticles |
| Zdroj: | International Conference on Atomic and Molecular Pulsed Lasers XIII. |
| DOI: | 10.1117/12.2303510 |
| Popis: | The work shows that iron oxide nanoparticles obtained in acoustoplasma discharge with cavitation affect the rate of one of the reactions of the process of blood coagulation - cleavage of fibrinogen by thrombin. As a result of the reaction, a fibrin gel is formed. By means of dynamic and static light scattering we reveal that adding of thrombin initially mixed with nanoparticles to the fibrinogen solution leads to dramatically acceleration of gel formation. Adding of nanoparticles to the solution of fibrinogen (before thrombin addition) leads to stopping of the reaction at the first stage (without gel formation). This data shows that ferrous oxide nanoparticles can act as regulators of enzyme reaction - in one case accelerating it, and in the other - by inhibiting it. Previously we presented the dynamics of distributions of the scattered light intensity on particle sizes in the fibrinogen-thrombin system with various sequences of nanoparticle addition. In this work we showed dynamics of the intensity correlation function in the samples, whose form becomes close to “stretched exponent” in pregel state or power law in a gel. |
| Databáze: | OpenAIRE |
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