To determine the effectiveness of antiepileptic drugs in treatment of acute traumatic brain injury for preventing seizure
| Autor: | null Shua Nasir, null Lal Shehbaz, null Muhammad Saad Usmani, null Alvia Saad, null Naveed Khan |
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| Rok vydání: | 2021 |
| Zdroj: | The Professional Medical Journal. 28:1737-1741 |
| ISSN: | 2071-7733 1024-8919 |
| DOI: | 10.29309/tpmj/2021.28.12.6494 |
| Popis: | Objectives: To determine the effectiveness of antiepileptic drugs in treatment of acute traumatic brain injury for preventing seizure. Study Design: Cross Sectional Study. Setting: Ziauddin Hospital, North Campus, Karachi. Period: 2014 to 2016. Material & Methods: Eighty diagnosed cases of traumatic brain injury were included in this study. Patients were examined physically and neurological assessment, with mental status was assessed by Glasgow Coma scoring. A blood sample was taken and Computed tomography was performed. Antiepileptic therapy was given for a period of one week minimally or 10 days maximally and patients were assessed clinically for seizures. All information was collected in the predesign proforma. Results: The patients median age was 25[16-43]. There were 70% male and 30% female. Rate of seizure was 6.3% (5/80) cases mortality was observed 5% (4/80) cases. Rate of seizure was significantly high in patients who had moderate TBI as compare to mild TBI (p=0.016). It was also significantly high in those cases who had diabetes and IHD. Rate of mortality was significantly high in seizure cases (p=0.0005). Conclusion: Prophylactic antiepileptic drugs are effective in decreasing the risk of early post-traumatic seizures in acute traumatic brain injury.These drug may provide an important and alternative treatment option for seizure prevention in acute TBI patients and prevent further brain damage. |
| Databáze: | OpenAIRE |
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