Semi-synthesis of a series natural flavonoids and flavonoid glycosides from scutellarin
| Autor: | Shiqiang Yan, Mingxian Xie, Yujie Wang, Qiang Xiao, Yingxia Li, Ning Ding |
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| Rok vydání: | 2020 |
| Předmět: |
Scutellarin
Flavonoid glycosides 010405 organic chemistry Structural similarity fungi Organic Chemistry food and beverages Structural diversity 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences chemistry.chemical_compound chemistry Drug Discovery Isolation techniques heterocyclic compounds |
| Zdroj: | Tetrahedron. 76:130950 |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2020.130950 |
| Popis: | Natural flavonoids and flavonoid glycosides exist in many plants and have been demonstrated to possess various clinically relevant properties, isolating large amounts of these compounds that have striking structural similarity from plant sources needs tedious isolation techniques. These processes limited their availability in structural diversity for structure−activity relationship (SAR) studies, and restrict large quantities for, as an example, their mechanistic evaluation of the in vivo activities. In this work, we developed a semi-synthetic strategy from scutellarin for the synthesis of a series of natural flavonoids and flavonoid glycosides. By taking this strategy, eight bioactive flavonoids with striking structural similarities were synthesized efficiently and practically. The sufficient amounts obtained products will greatly facilitate the SAR studies and mechanistic evaluation of the in vivo activities. |
| Databáze: | OpenAIRE |
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