Oral bioavailability of pivampicillin in foals at different ages
| Autor: | A. S. J. P. A. M. van Miert, J. M. Ensink, Arnold G. Vulto, W. R. Klein, A. Barneveld |
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| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Veterinary Quarterly. 16:113-116 |
| ISSN: | 1875-5941 0165-2176 |
| DOI: | 10.1080/01652176.1994.9694516 |
| Popis: | Summary The plasma disposition of ampicillin after intravenous administration at a dose rate of 15 mg/kg was studied in six healthy, 1‐month‐old foals. The oral bioavailability of pivampicillin was determined in the same foals at four ages, ranging from 11 days to 4 months. Pivampicillin was administered orally at a dose rate of 19.9 mg/kg, which is equivalent on a molecular basis to 15 mg/kg ampicillin. Ampicillin concentrations in plasma were determined up to 12 hours after administration. After intravenous administration, the mean distribution and elimination half‐lives of ampicillin were 0.121 and 0.624 h, respectively. The volume of distribution (Vss) appeared to be 0.334 1/kg. Orally administered pivampicillin was rapidly absorbed in all age groups, producing mean peak plasma concentrations of 3.83 to 5.69 μg/ml 1 h after administration. The mean bioavailability of pivampicillin in the different age groups ranged from 39.4 to 52.9 %. There was no statistically significant difference in peak plasma c... |
| Databáze: | OpenAIRE |
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