Evaluation of an HPLC Chiral Separation Flow Scheme for Small Molecules

Autor:	Donald S. Risley, Trent J. Oman, V. Scott Sharp, Lauren E. Starkey
Rok vydání:	2008
Předmět:	Imagination Chemical substance Chromatography Chemistry media_common.quotation_subject Clinical Biochemistry Pharmaceutical Science Biochemistry Small molecule High-performance liquid chromatography Analytical Chemistry Search engine Compatibility (mechanics) Enantiomer Science technology and society media_common
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 31:629-666
ISSN:	1520-572X 1082-6076
DOI:	10.1080/10826070701853693
Popis:	An HPLC chiral separation flow scheme was developed for identification of suitable enantioseparation conditions for small molecules. This flow scheme employs various chiral stationary phases (CSPs) and separation modes with the aim of improving efficiency by leading the scientist toward a reliable enantioseparation through a reduced number of experiments. In cases where a partial chiral separation is achieved with a particular CSP, guidance in the flow scheme is provided to improve resolution. Using prior knowledge, literature references, and data from 60 nonproprietary compounds analyzed in this study, the flow scheme was developed with separation mode (solvent compatibility) versatility in mind.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c54f6e7a52991c35d12dfe465384a829 https://doi.org/10.1080/10826070701853693 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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