A High Cytosol Value of Urokinase-Type Plasminogen Activator (uPA) May Be Predictive of Early Relapse in Primary Breast Cancer

Autor:	Giovanni Rosti, Giuseppe Lanzanova, Giovannini G, Maurizio Marangolo, A. Cariello, Claudio Dazzi, Petros Giovanis, Patrizia Maioli, Serena Magi
Rok vydání:	2003
Předmět:	Urokinase Cancer Research medicine.medical_specialty Angiogenesis Steroid hormone receptor Mammary gland Proteolytic enzymes General Medicine Biology medicine.disease Neovascularization Breast cancer medicine.anatomical_structure Endocrinology Oncology Internal medicine medicine Cancer research medicine.symptom Plasminogen activator medicine.drug
Zdroj:	Cancer Investigation. 21:208-216
ISSN:	1532-4192 0735-7907
DOI:	10.1081/cnv-120016417
Popis:	Background: There is now much data that suggest a relationship between angiogenesis and breast cancer prognosis. Angiogenesis is a multistep process resulting from an ordered set of events and regulated by positive and negative modulators of microvessels growth and by the expression of various proteolytic enzymes. Materials and methods: We prospectively evaluated VEGF and microvessels density on tumor specimen and cytosolic levels of uPA and PAI-1. Results: We enrolled 81 primary breast cancer patients. The median follow-up was 38 months. Using the median value as cutoff for the statistical analysis, we found significant correlation between cytosolic levels of uPA and PAI-1(r=0.61;p
Databáze:	OpenAIRE
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