Effect of the substitution of 3-methyl group on the carcinogenic activitiy of 2-naphthylamine

Autor:	G. V. Talwalkar, T. B. Panse, M. G. Kanekar
Rok vydání:	1967
Předmět:	chemistry.chemical_compound chemistry Stereochemistry Hydrochloride 2-Naphthylamine Male rats Substituent medicine Biological activity Carcinogenesis medicine.disease_cause Carcinogen Methyl group
Zdroj:	Proceedings / Indian Academy of Sciences. 65:257-266
ISSN:	0370-0097
DOI:	10.1007/bf03052550
Popis:	The carcinogenic activity of 3-methyl-2-naphthylamine (II) and its hydrochloride has been investigated with a view to studying the effect of 3-methyl substituent on the carcinogenic activity of 2-naphthylamine (I). It has been observed that: (1) Compared to compound (I), compound (II) is more carcinogenic to mice and rats. (2) Female rats are more susceptible than the male rats for the induction of tumour by (II) and its hydrochloride. (3) The subcutaneous injections of (II) induced fibrosarcomas in mice while the injections of its hydrochloride produced hemangioendotheliomas, local as well as at sites, distant from the site of application. From the biological activity of compound (II) it is inferred that the methyl group in (II) is involved in thein vivo carcinogenesis.
Databáze:	OpenAIRE
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