Speckle-type POZ adaptor protein (SPOP) and its role in cancer

Autor:	Wendy Johana Montero Ovalle, Martha Lucía Serrano López, María Carolina Sanabria Salas
Rok vydání:	2021
Předmět:	Cancer Research biology Oncogene Tumor suppressor gene Signal transducing adaptor protein Cancer Cellular homeostasis SPOP medicine.disease Ubiquitin ligase Oncology Ubiquitin biology.protein Cancer research medicine
Zdroj:	Revista Colombiana de Cancerología. 25:125-39
ISSN:	2346-0199 0123-9015
Popis:	Proteasomal degradation is an essential regulatory mechanism for cellular homeostasis maintenance. The speckle-type POZ adaptor protein (SPOP) is part of the ubiquitin ligase E3 cullin-3 RING-box1 complex, responsible for the ubiquitination and proteasomal degradation of biomolecules involved in cell cycle control, proliferation, response to DNA damage, epigenetic control, and hormone signaling, among others. Changes in SPOP have been associated with the development of different types of cancer, since it can act as a tumor suppressor mainly in prostate, breast, colorectal, lung cancer and liver cancer, due to point mutations and/or reduced expression, or as an oncogene in endometrial cancer, in which function gain has been found, and in kidney cancer by protein overexpression. SPOP is a potential prognostic biomarker and a promising therapeutic target.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c54646d9c471c481b27ef4b8ed9b05f0 https://doi.org/10.35509/01239015.717 Zobrazit plný text záznamu