In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2α overcomes the asthma-associated response

Autor:	N. Wood, M. O'Toole, Debra D. Donaldson, A.A. Hill, H. Legault, M. K. Ramarao, C.M. McKee, Marion T. Kasaian, G. Bensch, James R. Baker, G. W. Bensch, D. K. Ellis, C. Hang, C. Csimma, Padmalatha S. Reddy, A. J. Dorner, K. A. Whalen, J. D. Clark, J.L. Ryan
Rok vydání:	2008
Předmět:	Leukotriene Allergy business.industry Immunology Phospholipase medicine.disease_cause medicine.disease Peripheral blood mononuclear cell chemistry.chemical_compound Allergen chemistry Immunopathology medicine Immunology and Allergy Arachidonic acid business Asthma
Zdroj:	Clinical & Experimental Allergy. 38:1590-1605
ISSN:	1365-2222 0954-7894
Popis:	Background Existing treatments for asthma are not effective in all patients and disease exacerbations are common, highlighting the need for increased understanding of disease mechanisms and novel treatment strategies. The leukotriene pathway including the enzyme responsible for arachidonic acid release from cellular phospholipids, cPLA2α, is a major contributor to asthmatic responses and an attractive target in asthma therapies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c54454c589b1b7e83c767ea64e0eb763 https://doi.org/10.1111/j.1365-2222.2008.03059.x Zobrazit plný text záznamu Plný text ve formátu PDF