Effects of Gelam Honey on Oxidative Stress in Lung Cancer Cells
| Autor: | S. Raishan, Y.A. Mohd Yusof, G. Gunasekaran, Z. Nurul Faiznani, C A Muhamad Fitri, Noor Akmal Shareela Ismail, A B Hajar Amalnina, S. Chandrashegkar, Ja Goon |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
A549 cell Chemistry digestive oral and skin physiology food and beverages Cancer Pharmacology medicine.disease Malondialdehyde Protein oxidation medicine.disease_cause Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology medicine Hydrogen peroxide IC50 Oxidative stress |
| Zdroj: | Medicine & Health. 12:202-209 |
| ISSN: | 2289-5728 |
| DOI: | 10.17576/mh.2017.1202.05 |
| Popis: | Gelam honey was reported to exhibit anti-oxidative, anti-tumour and anti-inflammatory properties against many types of cancer. The main aim of the present study was to evaluate the effect of Gelam honey on the oxidative stress level of human lung cancer cells. IC50 of Gelam honey was identified by treating A549 cells with different doses of honey (50-200 mg/ml). The cells were divided into four groups and induced with stress using hydrogen peroxide (H2O2) accordingly: control, H2O2, Gelam honey, H2O2 + Gelam honey. After 24 hrs of treatment, oxidative stress markers such as malondialdehyde (MDA) and protein carbonyl, were determined. Induction of oxidative stress significantly increased the levels of MDA (p |
| Databáze: | OpenAIRE |
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