Comparative analysis of single- and dual-wavelength low dose photodynamic therapy regimens
| Autor: | Natalia Orlinskaya, D. A. Kurakina, Maria Shakhova, Aleksandr Khilov, Mikhail Yu. Kirillin |
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| Rok vydání: | 2019 |
| Předmět: |
Fluorescence-lifetime imaging microscopy
Materials science genetic structures medicine.diagnostic_test medicine.medical_treatment Low dose Photodynamic therapy Fluorescence eye diseases chemistry.chemical_compound chemistry Optical coherence tomography Chlorin medicine Dual wavelength Photosensitizer sense organs Biomedical engineering |
| Zdroj: | Medical Laser Applications and Laser-Tissue Interactions IX. |
| DOI: | 10.1117/12.2527108 |
| Popis: | Dual-wavelength photodynamic therapy is a photodynamic therapy (PDT) modality combining therapeutic effects of irradiation at two wavelengths of different region of visible range. In this paper we report on comparative analysis of single- and dual-wavelength PDT regimes based on multimodal optical monitoring of tissue response with histologic verification. Morphological and functional tissue responses to PDT procedure with chlorin-based photosensitizer (PS) were studied at the normal skin of a rabbit ear inner surface. Multimodal optical monitoring was performed by OCT and dual-wavelength fluorescence technique. The studied doses vary from 50 to 150 J/cm2 delivered separately at 405 or 660 nm, or at both wavelengths together in the equal dose. |
| Databáze: | OpenAIRE |
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