Anti-inflammatory Effects of Sinomenium Acutum Extract On Endotoxin-induced Uveitis in Lewis Rats
| Autor: | Tae Wan Kim, Hokyung Chung, Young Keun Han, Jeong Mo Han |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
food.ingredient business.industry medicine.drug_class Prostaglandin Inflammation General Medicine Pharmacology medicine.disease Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Ciliary body medicine.anatomical_structure food chemistry Medicine Tumor necrosis factor alpha medicine.symptom business Uveitis Sinomenine Sinomenium |
| Zdroj: | International Journal of Medical Sciences. 15:758-764 |
| ISSN: | 1449-1907 |
| DOI: | 10.7150/ijms.24834 |
| Popis: | PURPOSE Recent studies have reported the anti-inflammatory effect of Sinomenium acutum. We investigated the anti-inflammatory effect of sinomenine on endotoxin-induced uveitis in a rat model. METHODS Endotoxin-induced uveitis was induced in rat by lipopolysaccharide (LPS) immunization. Sinomenine (50mg/kg and 100mg/kg) was administered at 30 minutes before, 6 hours and 12 hours after LPS immunization. Clinical and histological severity was evaluated. Protein concentration and levels of tumor necrosis factor (TNF)-α and prostaglandin (PG)-E2 in aqueous humor were measured. Expression of activated Nuclear factor (NF)-κB p65 in ciliary body was also observed. RESULTS Clinical and histological severities were significantly milder in sinomenine-treated rat than in controls (P < 0.001). Sinomenine suppressed protein leakage and down-regulated the production of TNF-α and PG-E2 in a dose-dependent manner. Sinomenine treatment suppressed the translocation of the NF-κB p65 subunit into the nuclei. CONCLUSION Systemic administration of sinomenine suppressed the inflammation of ocular tissues. These findings suggest that sinomenine could be a novel therapeutic agent for the control of endogenous ocular inflammatory disease. |
| Databáze: | OpenAIRE |
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