1789 FOLLOWUP AFTER A CONSERVATIVE APPROACH OF LOW GRADE UPPER URINARY TRACT TOMOURS: CHANGING THE PATTERNS
| Autor: | Oscar Rodriguez Faba, Josep M Gaya, Giuseppe Lucarelli, Humberto Villavicencio, Alberto Breda, J. Martí, Juan Palou, Lluís Gausa, Pablo de la Torre, Marco Cosentino |
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| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Journal of Urology. 189 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/j.juro.2013.02.3232 |
| Popis: | and 2009 archived at our institution. A total of 330 patients with initially diagnosed NMIBC were identified. The use of antihypertensive drugs at TUR-BT was reviewed focusing on the use of RAS inhibitors and other agents (calcium-channel blockers, ƒA-blockers, and diuretics). We retrospectively investigated the clinical outcomes following TUR-BT in patients who did or did not administer RAS inhibitors. The median follow-up period was 4.1 years. RESULTS: A total of 128 patients (38.8%) experienced subsequent tumor recurrence during follow-up. One hundred sixteen patients (35.2%) received medications for hypertension at TUR-BT. Fifty-one patients (15.5%) had received ACEI or ARB administration. Multivariate analysis demonstrated that tumor multiplicity, the absence of BCG instillation, and no ACEI or ARB administration (P 0.010 HR 2.26) were independent risk factors for subsequent tumor recurrence. The 5-year recurrence-free survival rate was 78.4% in patients administered ACEIs or ARBs, and 53.3% in their counterparts (p 0.011). CONCLUSIONS: The absence of RAS inhibitor administration was an independent risk factor for subsequent tumor recurrence in patients with initially diagnosed NMIBC. Our data supports further investigation of the RAS inhibitors as a potential therapy to decrease tumor recurrence in NMIBC. |
| Databáze: | OpenAIRE |
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