The Efficacy of Costus igneus Rhizome on Carbohydrate Metabolic, Hepatoproductive and Antioxidative Enzymes in Streptozotocin-induced Diabetic Rats
| Autor: | Pazhanichamy Kalailingam, Kumaran Shanmugam, Aiswarya Devi Sekar, Eevera Tamilmani, Jeba Samuel Clement Samuel, Rajendran Kaliaperumal, Manjula Kesavan, Yogha Govindaraju, Priya Gandhirajan |
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| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant biology Glucokinase Health Toxicology and Mutagenesis medicine.medical_treatment Glutathione peroxidase Diosgenin Glutathione Toxicology Streptozotocin chemistry.chemical_compound Endocrinology chemistry Catalase Internal medicine biology.protein medicine Alkaline phosphatase medicine.drug |
| Zdroj: | JOURNAL OF HEALTH SCIENCE. 57:37-46 |
| ISSN: | 1347-5207 1344-9702 |
| DOI: | 10.1248/jhs.57.37 |
| Popis: | In this study, effect of an ethanolic extract from rhizome of Costus igneus were investigated on activity of following enzyme in liver, kidney, pancreas of streptozotocin (STZ) induced diabetic rats: carbohydrate metabolic enzymes such as glucokinase glucose-6-phosphatase, and fructose-1,6-bisphosphatase in the liver; hepatoproductive enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in plasma and liver; and antioxidative enzymes such as superoxide dimutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione content (GSH), total sulfhydryl groups (TSH), lipid peroxides (LPO) in liver, kidney and pancreas. An ethanol extract from Costus igneus rhizome was administrated orally at a single dose of 100 or 200 mg/kg per day to diabetes induced rats for 30 days. This study demonstrated that glucose-6-phosphatase fructose-1,6-bisphosphatase, AST, ALT, ALP and LPO levels were significantly increased (p |
| Databáze: | OpenAIRE |
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