Hypervalent iodine oxidation: α-Functionalization of β-dicarbonyl compounds using iodosobenzene

Autor:	Robert M. Moriarty, V. T. Ravikumar, Radhe K. Vaid, T. E. Hopkins, B. K. Vaid
Rok vydání:	1988
Předmět:	Diketone Iodosobenzene Chloroform Methyl phenylacetate Organic Chemistry Hypervalent molecule Biochemistry Medicinal chemistry chemistry.chemical_compound chemistry Nucleophile Drug Discovery Organic chemistry Azide Aliphatic compound
Zdroj:	Tetrahedron. 44:1603-1607
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)86720-x
Popis:	Hypervalent iodine oxidation of β-diketones and β-ketoesters with iodosobenzene-boron trifluoride etherate in chloroform using appropriate nucleophiles results In α-functionalization. Benzoylacetone on reaction with iodosobenzene or iodosobenzene boron trifluoride-etherate in methanol yields α-methoxyacetophenone ( 9 ) and methyl phenylacetate ( 10 ). The possible mechanisms for these reactions are discussed.
Databáze:	OpenAIRE
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