| Popis: |
Controlled releasing drug delivery systems (CRDDS) are proved to be superior over the conventional immediate releasing dosage systems in numerous aspects such as lower incidences of dose dumping risks and side-effect problems, reduced frequency of dosing, enhanced bioavailability, and better patient compliances. Polyelectrolyte complexes (PECs) are one of the most promising polymeric systems used to control the drug release kinetics. Since last few decades, alginate-based PECs are gaining much attention in the development of CRDDS and have brought a revolution in this domain due to their nontoxicity, biodegradability, abundantly availability, eco-friendliness, and inexpensiveness. Moreover, the alginates have the ability to mingle with other polymers without losing their own identity and are being used for controlling the drug release kinetics in a superior way. In this regard, contribution of alginate-cationic starch PECs, alginate-cationized poly- l -lysine PECs, alginate-cationized gelatin PECs, and alginate–chitosan PECs are noteworthy. |
