Association of Catalase and Glutathione Peroxidase 1 Polymorphisms with Chronic Hepatitis C Outcome
| Autor: | Luydson Richardson Silva Vasconcelos, Maria do Socorro de Mendonça Cavalcanti, Patrícia Moura, Rodrigo Feliciano do Carmo, Dayse Celia Barbosa Lins Aroucha, Vanessa C.S.D. Sousa, Leila Maria Moreira Beltrão Pereira |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification GPX1 biology Hepatitis C virus Glutathione peroxidase Single-nucleotide polymorphism medicine.disease medicine.disease_cause digestive system diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine chemistry Catalase Fibrosis 030220 oncology & carcinogenesis Hepatocellular carcinoma Immunology Genotype Genetics biology.protein medicine Genetics (clinical) |
| Zdroj: | Annals of Human Genetics. 80:145-153 |
| ISSN: | 0003-4800 |
| Popis: | The hepatic damage caused by hepatitis C virus (HCV) infection is associated with the host immune response and viral regulatory factors. Catalase (CAT) and glutathione peroxidase 1 (GPX1) are antioxidant enzymes located in the peroxisomes and mitochondria, respectively, and are responsible for the control of intracellular hydrogen peroxide levels. Polymorphisms in CAT (C-262T) and GPX1 (Pro198Leu) are correlated with serum levels and enzyme activity. This study aimed to investigate the association of genetic polymorphisms of CAT C-262T (rs1001179) and GPX1 Pro198Leu (rs1050450) with different stages of liver fibrosis and development of hepatocellular carcinoma (HCC). This study included 445 patients with chronic hepatitis C, of whom 139 patients had mild fibrosis (F0-F1), 200 had moderate/severe fibrosis (F2-F4), and 106 had HCC. Genotyping of SNPs was performed by real-time PCR using TaqMan probes. The Pro/Pro genotype of GPX1 was significantly associated with fibrosis severity, HCC, Child Pugh score, and BCLC staging. Additionally, patients carrying both CT+TT genotypes in the CAT gene and the Pro/Pro genotype in the GPX1 gene had higher risk for developing moderate/severe fibrosis or HCC (p = 0.009, OR 2.40 and p = 0.002, OR 3.56, respectively). CAT and GPX1 polymorphisms may be implicated in the severity of liver fibrosis and HCC caused by HCV. |
| Databáze: | OpenAIRE |
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