Complexation of Scandium with Oxabis(ethylenenitrilo)tetramethylenephosphonic Acid and Applicability of Its 44Sc-Labelled Analogue as Bone-Seeking Agent

Autor:	Yu. A. Mitrofanov, A. A. Larenkov, G. E. Kodina
Rok vydání:	2021
Předmět:	Clinical Practice Deprotonation chemistry Stability constants of complexes Bone lesion Potentiometric titration Ph range chemistry.chemical_element General Chemistry Scandium Spectroscopy Nuclear chemistry
Zdroj:	Russian Journal of General Chemistry. 91:202-214
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363221020080
Popis:	The regularities of complexation of scandium with oxabis(ethylenenitrilo)tetramethylenephosphonic acid (OBEP), which is actively used nowadays in the clinical practice for the synthesis of bone-seeking radiopharmaceuticals, have been studied by means of potentiometric titration and NMR spectroscopy. The stability constant of the deprotonated complex (log β110 = 20.25 ± 0.74, 0.1 M NaClO4, 25°C) and the pH range of effective binding of scandium to OBEP (3 to 9) have been found comparable to these of similar lanthanide complexes. The possibility of efficient synthesis of [44Sc]Sc–OBEP complexes without an isotopic carrier with radiochemical purity of at least 98% has been shown. Preliminary evaluation of the applicability of [44Sc]Sc–OBEP complex as a bone-seeking radiopharmaceutical for PET visualization of metabolic skeletal lesions has been performed. The accumulation of [44Sc]Sc–OBEP in the bone lesion has been found to be 3.0–3.5 times higher than that in the intact bone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::c51271084c38a474dffc6209dc9e521e https://doi.org/10.1134/s1070363221020080 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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