Evaluating the correlation of the impairment between skeletal muscle and heart using MRI in a spontaneous type 2 diabetes mellitus rhesus monkey model
| Autor: | Jie Zheng, Zunyuan Yang, Fabao Gao, Tong Zhu, Lei Wang, Bin Song, Yushu Chen, Wen Zeng, Li Gong, Wei Chen, Fangtong Wang, Yinan Liang, Jiayu Sun, Bing Wu, Zhigang Liang, Yu Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Soleus muscle
medicine.medical_specialty Ejection fraction business.industry Endocrinology Diabetes and Metabolism Diastole Skeletal muscle 030209 endocrinology & metabolism Strain (injury) General Medicine 030204 cardiovascular system & hematology medicine.disease Microcirculation 03 medical and health sciences Gastrocnemius muscle 0302 clinical medicine Endocrinology medicine.anatomical_structure Tibialis anterior muscle Internal medicine Internal Medicine medicine Cardiology business |
| Zdroj: | Acta Diabetologica. 57:673-679 |
| ISSN: | 1432-5233 0940-5429 |
| DOI: | 10.1007/s00592-019-01460-0 |
| Popis: | To investigate the correlation of impairment in skeletal muscle and heart in spontaneous type 2 diabetes mellitus (T2DM) rhesus monkeys using magnetic resonance image (MRI). Fifteen T2DM monkeys and fourteen healthy control (HC) monkeys were included. The microcirculation of skeletal muscle [skeletal muscle blood flow (SMBF), skeletal muscle oxygen extraction fraction (SMOEF)] and the function and strain of heart were evaluated by MRI. Three regions of interests were chosen on the soleus muscle (SOL), gastrocnemius muscle (GAS) and tibialis anterior muscle (TA) for image analysis. Eight T2DM monkeys and eight HC monkeys were obtained the full data. The SMBF reserves and SMOEF reserves were found significantly decreased in T2DM during inflation in SOL, GAS and TA muscles (all p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink