Three new diterpenes from the seeds of Caesalpinia minax Hance and their anti-inflammatory activity
| Autor: | Depo Yang, Sheng-qing Wu, Bai Bai, Qin Liu, Zhimin Zhao, Long-Ping Zhu, Juan Shen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Lipopolysaccharide
Traditional medicine 010405 organic chemistry medicine.drug_class Moderate activity Plant Science 01 natural sciences Biochemistry Anti-inflammatory 0104 chemical sciences Nitric oxide Caesalpinia minax 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry medicine Agronomy and Crop Science IC50 Biotechnology |
| Zdroj: | Phytochemistry Letters. 26:93-95 |
| ISSN: | 1874-3900 |
| Popis: | Three new diterpenes, caesalmin U (1), caesalmin V (2) and caesalmin W (3), were isolated from the EtOAc extract of the seeds of Caesalpinia minax Hance. Their structures were mainly characterized on the basis of extensive spectroscopic analyses and comparison with reported data. The inhibitory activities of nitric oxide (NO) production release of RAW 264.7 cells stimulated by lipopolysaccharide (LPS) of compounds 1-3 were evaluated, and compound 1 displayed moderate activity with IC50 value of 23.72 μM. |
| Databáze: | OpenAIRE |
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