Effects of Zingiber officinale extract supplementation on metabolic and genotoxic parameters in diet-induced obesity in mice
| Autor: | Claudio Teodoro De Souza, Paulo Cesar Lock da Silveira, Thais F. Luciano, Natalia dos Santos Tramontin, Vanessa Moraes de Andrade, Ricardo A. Pinho, Alexandre Pastoris Muller, Gabriel Paulino Luiz, Schérolin de Oliveira Marques |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Antioxidant medicine.medical_treatment Medicine (miscellaneous) medicine.disease_cause Proinflammatory cytokine Superoxide dismutase 03 medical and health sciences 0302 clinical medicine Insulin resistance Oral administration Internal medicine Diabetes mellitus medicine Nutrition and Dietetics biology business.industry nutritional and metabolic diseases medicine.disease 030104 developmental biology Endocrinology Catalase 030220 oncology & carcinogenesis biology.protein business Oxidative stress |
| Zdroj: | British Journal of Nutrition. 126:970-981 |
| ISSN: | 1475-2662 0007-1145 |
| Popis: | Obesity is an epidemic associated with many diseases. The nutraceutical Zingiber officinale (ZO) is a potential treatment for obesity; however, the molecular effects are unknown. Swiss male mice were fed a high-fat diet (59 % energy from fat) for 16 weeks to generate a diet-induced obesity (DIO) model and then divided into the following groups: standard diet + vehicle; standard diet + ZO; DIO + vehicle and DIO + ZO. Those in the ZO groups were supplemented with 400 mg/kg per d of ZO extract (oral administration) for 35 d. The animals were euthanised, and blood, quadriceps, epididymal fat pad and hepatic tissue were collected. DIO induced insulin resistance, proinflammatory cytokines, oxidative stress and DNA damage in different tissues. Treatment with ZO improved insulin sensitivity as well as decreased serum TAG, without changes in body weight or adiposity index. TNF-α and IL-1β levels were lower in the liver and quadriceps in the DIO + ZO group compared with the DIO group. ZO treatment reduced the reactive species and oxidative damage to proteins, lipids and DNA in blood and liver in obese animals. The endogenous antioxidant activity was higher in the quadriceps of DIO + ZO. These results in the rat model of DIO may indicate ZO as an adjuvant on obesity treatment. |
| Databáze: | OpenAIRE |
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