Chain-growth simulations of the HP model for proteins
| Autor: | Michael Bachmann, Paulo H. L. Martins, Fabricio S H Santos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Physics::Biological Physics Quantitative Biology::Biomolecules History Diagram Thermodynamics Sequence (biology) Polymer Square (algebra) Computer Science Applications Education Condensed Matter::Soft Condensed Matter Crystallography chemistry Pectate lyase Helix Radius of gyration Polar |
| Zdroj: | Journal of Physics: Conference Series. 686:012003 |
| ISSN: | 1742-6596 1742-6588 |
| DOI: | 10.1088/1742-6596/686/1/012003 |
| Popis: | We consider a generalized hydrophobic-polar model for proteins on square lattices. Besides the attraction between nonbonded hydrophobic monomers, the present model also takes into account an interaction between hydrophobic and polar units. By using the pruned- enriched Rosenbluth method (PERM), we investigate a specific polymer sequence composed of 42 monomers that has been proposed to simulate the physical properties of the parallel β- helix of pectate lyase C. For each temperature, the total number of generated chains varies from 106 to 107. Physical observables such as specific heat, total energy, end-to-end distance, radius of gyration, and the average number of hydrophobic-hydrophobic and hydrophobic-polar contacts are evaluated for different values of the ratio between the hydrophobic-hydrophobic and the hydrophobic-polar contact energies. Eventually, a pseudo-phase diagram in the space of temperature and the ratio of contact energy scales is constructed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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