New Concepts for Evaluating the Performance of Computational Methods * *The author acknowledge financial support by the by the German Ministry of Education and Research (BMBF) via e:Bio Grant No. 031L0080
| Autor: | Clemens Kreutz |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Reverse engineering Management science Computer science Systems biology Experimental data Context (language use) computer.software_genre Experimental research Variety (cybernetics) 03 medical and health sciences 030104 developmental biology Drug development Control and Systems Engineering Selection (linguistics) computer |
| Zdroj: | IFAC-PapersOnLine. 49:63-70 |
| ISSN: | 2405-8963 |
| DOI: | 10.1016/j.ifacol.2016.12.104 |
| Popis: | Research in Systems Biology is currently entering a new era. After a decade characterized by adopting existing experimental protocols and theoretical approaches to the requirements of Systems Biology, there is now a variety of tools and approaches available. However, many statistical and modeling concepts are not well-tested in application settings and their applicability is often seriously delimited. Therefore, a major challenge for the transfer of theoretical approaches to applications is the assessment and optimization of the methods’ performance for supporting experimental research. In this paper, new concepts for assessing methods which were developed for analyzing experimental data in the context of systems biology will be introduced. Some ideas are illustrated by evaluating the impact of the logarithmic transformation for parameter estimation. A strong benefit of the log-transformation was observed for five different ODE models. The suggested framework enables less biased and more reliable and valid assessment and comparison of competing approaches than currently performed in the literature. The presented concepts could serve as basis for developing decision guidelines for optimal selection of analysis methods and thereby enhancing the transfer of systems biological procedures and reverse engineering methods to industrial applications like drug development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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