LncRNA CASC11 is upregulated in postmenopausal osteoporosis and is correlated with TNF-α
| Autor: | Hao-Tao Yu, Ping Zhang, Yinhao Xie, Zhong-Qi Xu, Weiming Yan, Wei Zhou |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Cancer susceptibility General Medicine Plasma levels Postmenopausal osteoporosis Endocrinology Western blot Downregulation and upregulation Internal medicine Medicine Tumor necrosis factor alpha Geriatrics and Gerontology business After treatment Prolonged treatment |
| Zdroj: | Clinical Interventions in Aging. 14:1663-1669 |
| ISSN: | 1178-1998 |
| Popis: | Purpose In this study, we aimed to investigate the role of lncRNA cancer susceptibility 11 (CASC11) and tumor necrosis factor (TNF-α) in postmenopausal osteoporosis (POP). Methods and materials POP patients and healthy controls were included in this study and levels of CASC11 and TNF-α in plasma of those participants were measured by qPCR and Western blot, respectively. ROC curve was used for diagnostic analysis. Patients were followed up for 2 years and the correlations between the levels of CASC11 and TNF-α and disease conditions were analyzed. Results We found that CASC11 and TNF-α were both upregulated in plasma of POP patients than in healthy controls. Plasma levels of CASC11 and TNF-α were positively correlated in both POP patients and in healthy controls. Upregulation of CASC11 and TNF-α distinguished POP patients from healthy controls. Treatment and follow-up study showed that high CASC11 levels were significantly correlated with prolonged treatment course and high recurrence rate. Plasma levels of CASC11 and TNF-α decreased after treatment. CASC11 overexpression led to upregulated TNF-α in osteoclasts. Conclusion CASC11 is upregulated in POP and is correlated with TNF-α. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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