Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients
| Autor: | Simone Boskamp, Leslie D. Isken, Janko van Beek, Adam Meijer, Mariken van der Lubben, Menno D. de Jong, Gé A. Donker, Ingrid H M Friesema, Arianne B van Gageldonk-Lafeber, Marianne A B van der Sande, Marion Koopmans, Jan M. Prins |
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| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Epidemiology business.industry viruses Public Health Environmental and Occupational Health Outbreak Virus Diarrhea Infectious Diseases Immune system Internal medicine Immunology Pandemic medicine Human mortality from H5N1 medicine.symptom Young adult business Viral load |
| Zdroj: | Influenza and Other Respiratory Viruses. 6:e16-e20 |
| ISSN: | 1750-2640 |
| DOI: | 10.1111/j.1750-2659.2012.00347.x |
| Popis: | Please cite this paper as: Friesema et al. (2012). Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients. Influenza and Other Respiratory Viruses 6(3), e16–e20. The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance. |
| Databáze: | OpenAIRE |
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