Effect of 21-day Dry Immersion on the Production of Cytokines Involved in the Regulation of Bone Metabolism by T Cells
| Autor: | V. A. Smarov, S. A. Kalinin, A. A. Sadova, S. A. Ponomarev, O.V. Kutko, M. P. Rykova, E. N. Antropova, D. D. Kiseleva, S. M. Shulgina, G. Yu. Vassilieva, K.D. Orlova |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
biology Physiology Chemistry CD3 05 social sciences CD28 Metabolism Bone tissue 050105 experimental psychology In vitro Bone remodeling 03 medical and health sciences 0302 clinical medicine Endocrinology medicine.anatomical_structure Physiology (medical) Internal medicine medicine biology.protein 0501 psychology and cognitive sciences Secretion IL-2 receptor 030217 neurology & neurosurgery |
| Zdroj: | Human Physiology. 46:787-791 |
| ISSN: | 1608-3164 0362-1197 |
| DOI: | 10.1134/s0362119720070099 |
| Popis: | Activated T cells from peripheral blood of six volunteers, participants of the experiment with 21-day dry immersion (DI), were analyzed. The results of analysis of the synthesis of cytokines affecting the metabolism of bone tissue and contributing to the maintenance of its physiological homeostasis are presented. We have shown that prolonged restriction of motor loads leads to an increase in the content of peripheral blood activated CD3+CD25+ T cells. The monocultures of peripheral blood CD3+ cells stimulated in vitro with anti-CD2/CD3/CD28 complex for 24 h revealed changes in the cytokines synthesis. Two different types of response of activated T cells to prolonged exposure to DI have been demonstrated: either an increase or a decrease in the secretion of cytokines stimulating increased bone resorption (IL-1β, IL-6, IL-8, IL-17A, TNF-α, GM-CSF) and weakening osteoclastogenesis (IFN-γ, IL-3, IL-4, IL-10, IL-13). |
| Databáze: | OpenAIRE |
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